Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

Arch Biochem Biophys. 2011 Jun 15;510(2):93-100. doi: 10.1016/ Epub 2011 Apr 14.


Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9+2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

Publication types

  • Review

MeSH terms

  • Animals
  • Axoneme / enzymology*
  • Axoneme / metabolism
  • Cilia / enzymology*
  • Cilia / metabolism
  • Conserved Sequence*
  • Humans
  • Movement*
  • Phosphoric Monoester Hydrolases / chemistry
  • Phosphoric Monoester Hydrolases / metabolism*
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism*


  • Protein Kinases
  • Phosphoric Monoester Hydrolases