Structural biology of Mycobacterium tuberculosis proteins: the Indian efforts

Tuberculosis (Edinb). 2011 Sep;91(5):456-68. doi: 10.1016/ Epub 2011 Apr 22.


Among the many different objectives of large scale structural genomics projects are expanding the protein fold space, enhancing understanding of a model or disease-related organism, and providing foundations for structure-based drug discovery. Systematic analysis of protein structures of Mycobacterium tuberculosis has been ongoing towards meeting some of these objectives. Indian participation in these efforts has been enthusiastic and substantial. The proteins of M. tuberculosis chosen for structural analysis by the Indian groups span almost all the functional categories. The structures determined by the Indian groups have led to significant improvement in the biochemical knowledge on these proteins and consequently have started providing useful insights into the biology of M. tuberculosis. Moreover, these structures form starting points for inhibitor design studies, early results of which are encouraging. The progress made by Indian structural biologists in determining structures of M. tuberculosis proteins is highlighted in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Computational Biology
  • Crystallography, X-Ray
  • Genome, Bacterial*
  • Humans
  • India
  • Molecular Biology
  • Mycobacterium tuberculosis / genetics*


  • Bacterial Proteins