Abstract
Oleoyl Formononetin (OF) has good weight loss activity and hypolipidemic activity, could improve insulin sensitivity and suppress adipogenesis. To acquire better biological activities, three series of flavonoid fatty acid esters were designed and synthesized by optimizing the structure of OF. Their bioactivities were assayed in vitro. Some of these novel compounds could effectively inhibit preadipocyte proliferation and adipogenesis. Moreover, they could enhance glucose consumption in adipocytes notably.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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3T3-L1 Cells
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Adipocytes / cytology
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Adipocytes / drug effects
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Adipogenesis / drug effects*
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Animals
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Anti-Obesity Agents / chemical synthesis
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / pharmacology*
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Cell Proliferation / drug effects
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Esters / chemical synthesis
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Esters / chemistry
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Esters / pharmacology
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Fatty Acids / chemical synthesis
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Fatty Acids / chemistry
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Fatty Acids / pharmacology*
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Flavonoids / chemical synthesis
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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Glucose / metabolism*
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Mice
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Models, Molecular
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Obesity / drug therapy
Substances
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Anti-Obesity Agents
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Esters
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Fatty Acids
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Flavonoids
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Glucose