Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Nat Chem Biol. 2011 Jun;7(6):348-50. doi: 10.1038/nchembio.559. Epub 2011 Apr 24.


Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Drug Evaluation, Preclinical
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Synergism
  • Drug Therapy, Combination / methods*
  • Minocycline / pharmacology
  • Minocycline / therapeutic use


  • Anti-Bacterial Agents
  • Minocycline

Associated data

  • PubChem-Substance/116933598
  • PubChem-Substance/116933599
  • PubChem-Substance/116933600
  • PubChem-Substance/116933601
  • PubChem-Substance/116933602
  • PubChem-Substance/116933603
  • PubChem-Substance/116933604
  • PubChem-Substance/116933605
  • PubChem-Substance/116933606
  • PubChem-Substance/116933607