[Metabolic correctors based on succinic acid as pathogenic therapy in chronic virus hepatitis]

Ter Arkh. 2011;83(2):67-71.
[Article in Russian]

Abstract

Chronic viral hepatitides (CVH) run with long-term activation of the system of mononuclear phagocytes associated with hyperproduction of active oxygen forms. This can be considered as risk factors of antioxidant insufficiency which determines the course of the disease. Now, antioxidant, cytoprotective medicines are more and more actively used in hepatology. The results are reviewed of many Russian clinical trials of efficacy of metabolic correctors based on siccine acid (reamberin, remaxol) as pathogenetic treatment in CVH. Metabolic correctors in combined treatment of CVH improve basic clinico-laboratory indices, raise efficacy of basic therapy, correct insufficiency of antioxidant defense. The results of the studies confirm advantage of antihypoxic medication over standard infusion therapy for treatment of CVH patients.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Cytoprotection
  • Hepatitis B, Chronic / drug therapy
  • Hepatitis B, Chronic / metabolism*
  • Hepatitis C, Chronic / drug therapy
  • Hepatitis C, Chronic / metabolism*
  • Humans
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology*
  • Succinic Acid / therapeutic use*
  • Treatment Outcome

Substances

  • Succinic Acid