The relationship between suppression of acidity and gastric ulcer healing rates

Aliment Pharmacol Ther. 1990 Feb;4(1):25-33. doi: 10.1111/j.1365-2036.1990.tb00445.x.


We have investigated the relationship between the suppression of acidity by antisecretory drugs for the treatment of benign gastric ulcer and their corresponding ulcer-healing rates. For a variety of antisecretory drug regimens, there was a significant correlation between suppression of 24-h intragastric acidity and ulcer healing rates after 2, 4 and 8 weeks of treatment. There was a lesser degree of correlation between healing and suppression of nocturnal acidity and the association between suppression of acidity and gastric-ulcer healing rates was less marked than that previously described for duodenal ulcer.

Publication types

  • Meta-Analysis

MeSH terms

  • Antacids / therapeutic use*
  • Anti-Ulcer Agents / therapeutic use*
  • Gastric Acid / physiology*
  • Humans
  • Meta-Analysis as Topic
  • Stomach Ulcer / drug therapy*


  • Antacids
  • Anti-Ulcer Agents