Wnt5a: its signalling, functions and implication in diseases

Acta Physiol (Oxf). 2012 Jan;204(1):17-33. doi: 10.1111/j.1748-1716.2011.02294.x. Epub 2011 Apr 22.


Wnt5a is a representative ligand that activates the β-catenin-independent pathways. Because the β-catenin-independent pathway includes multiple signalling cascades in addition to the planar cell polarity and Ca(2+) pathway, Wnt5a regulates a variety of cellular functions, such as proliferation, differentiation, migration, adhesion and polarity. Consistent with the multiple functions of Wnt5a signalling, Wnt5a knockout mice show various phenotypes, including an inability to extend the embryonic anterior-posterior and proximal-distal axes in outgrowth tissues. Thus, many important roles of Wnt5a in developmental processes have been demonstrated. Moreover, recent reports suggest that the postnatal abnormalities in the Wnt5a signalling are involved in various diseases, such as cancer, inflammatory diseases and metabolic disorders. Therefore, Wnt5a and its signalling pathways could be important targets for the diagnosis and therapy for human diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cell Differentiation
  • Cell Movement
  • Disease*
  • Endocytosis / physiology
  • Frizzled Receptors / genetics
  • Frizzled Receptors / metabolism
  • Humans
  • Mice
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Signal Transduction / physiology*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism*
  • Wnt-5a Protein
  • Wnt3A Protein / genetics
  • Wnt3A Protein / metabolism
  • beta Catenin / metabolism


  • Frizzled Receptors
  • Protein Isoforms
  • Wnt Proteins
  • Wnt-5a Protein
  • Wnt3A Protein
  • Wnt5a protein, mouse
  • beta Catenin