[Association between apolipoprotein A5 gene polymorphism and coronary heart disease in the Han population from Xinjiang]

Zhonghua Liu Xing Bing Xue Za Zhi. 2011 Jan;32(1):51-4.
[Article in Chinese]

Abstract

Objective: The aim is to investigate the association between coronary heart disease (CHD) and c.553G>T polymorphism of apolipoprotein A5 (ApoA5) gene and the influence of serum lipid level in the Han ethnic population of Xinjiang.

Methods: The polymorphism of ApoA5 gene in 486 patients with CHD and 501 controls was analyzed by methods of polymerase chain reaction and restriction fragment length polymorphism analysis. Level of serum lipid in each patient was detected at the same time.

Results: There was significant difference in the distribution of genotypes between CHD group and controls group (χ(2)=8.757, P=0.013). Non-conditioned logistic regression analyses, after adjusted for age, gender, smoking, total serum cholesterol, presence of hypertension and diabetes, revealed that individuals who carried T allele (TT + GT genotype) had an increased risk of CHD, compared to GG genotype (OR=1.753, 95%CI: 1.030-2.983, P<0.05). There was also a remarkable difference noticed in the level of serum triglyceride by genotypes in CHD group and control group (t=-5.242, P<0.01; t=-3.499, P=0.001). Individuals in the two groups who carried T allele had higher level of serum triglyceride than those carried GG genotype. Individuals in CHD group who carried T allele had higher level of serum total cholesterol than those carried GG genotype (t=-2.465, P=0.014).

Conclusion: It seemed that the c.553G>T polymorphism of ApoA5 gene had influenced on the level of serum triglyceride and the total cholesterol among Han population in Xinjiang. c.553G>T polymorphism was associated with the development of CHD, while T allele might be an influencing risk factor on CHD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Apolipoprotein A-V
  • Apolipoproteins A / genetics*
  • Asian People / genetics
  • Coronary Disease / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Risk Factors

Substances

  • APOA5 protein, human
  • Apolipoprotein A-V
  • Apolipoproteins A