PI3K and chemotaxis: a priming issue?

Sci Signal. 2011 Apr 26;4(170):pe22. doi: 10.1126/scisignal.2002019.


Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Chemotaxis / physiology*
  • Dictyostelium / cytology
  • Dictyostelium / physiology
  • Humans
  • Neutrophils / cytology
  • Neutrophils / physiology
  • Phosphatidylinositol 3-Kinases / physiology*
  • Signal Transduction / physiology


  • Phosphatidylinositol 3-Kinases