Subversion of the actin cytoskeleton during viral infection

Nat Rev Microbiol. 2011 Jun;9(6):427-39. doi: 10.1038/nrmicro2574. Epub 2011 Apr 27.


Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / chemistry
  • Actins / metabolism*
  • Adenoviridae / physiology
  • Animals
  • Cell Transformation, Viral / physiology
  • Cytoskeleton / metabolism*
  • Endocytosis / physiology
  • Hepatitis B virus / physiology
  • Herpesviridae / physiology
  • Humans
  • Rous sarcoma virus / physiology
  • Simian virus 40 / physiology
  • Viral Proteins / metabolism
  • Virion / physiology
  • Virus Assembly
  • Virus Replication / physiology*
  • rho GTP-Binding Proteins / metabolism


  • Actins
  • Viral Proteins
  • rho GTP-Binding Proteins