Abstract
Gynecomastia and rapid growth progressed in twin brothers and pubic hair in one, over a period of 2 years. A combination of contra- and isosexual development was induced by transdermal exposure to compounded estradiol, estrone, and testosterone creams applied to their mother's body as part of a hormone replacement regimen.
MeSH terms
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Administration, Cutaneous
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Age Determination by Skeleton
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Child, Preschool
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Drug Compounding
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Estradiol / administration & dosage
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Estradiol / adverse effects
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Estradiol / blood
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Estrone / administration & dosage
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Estrone / adverse effects
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Estrone / blood
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Gonadal Steroid Hormones / administration & dosage
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Gonadal Steroid Hormones / adverse effects*
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Gynecomastia / chemically induced*
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Hormone Replacement Therapy / adverse effects
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Humans
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Male
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Menopause
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Puberty, Precocious / chemically induced*
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Testosterone / administration & dosage
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Testosterone / adverse effects
Substances
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Gonadal Steroid Hormones
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Estrone
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Testosterone
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Estradiol