Effects of unintentional exposure of children to compounded transdermal sex hormone therapy

Pediatr Endocrinol Rev. 2011 Mar;8(3):208-12.

Abstract

Gynecomastia and rapid growth progressed in twin brothers and pubic hair in one, over a period of 2 years. A combination of contra- and isosexual development was induced by transdermal exposure to compounded estradiol, estrone, and testosterone creams applied to their mother's body as part of a hormone replacement regimen.

Publication types

  • Case Reports

MeSH terms

  • Administration, Cutaneous
  • Age Determination by Skeleton
  • Child, Preschool
  • Drug Compounding
  • Estradiol / administration & dosage
  • Estradiol / adverse effects
  • Estradiol / blood
  • Estrone / administration & dosage
  • Estrone / adverse effects
  • Estrone / blood
  • Gonadal Steroid Hormones / administration & dosage
  • Gonadal Steroid Hormones / adverse effects*
  • Gynecomastia / chemically induced*
  • Hormone Replacement Therapy / adverse effects
  • Humans
  • Male
  • Menopause
  • Puberty, Precocious / chemically induced*
  • Testosterone / administration & dosage
  • Testosterone / adverse effects

Substances

  • Gonadal Steroid Hormones
  • Estrone
  • Testosterone
  • Estradiol