Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May 27;332(6033):1093-7.
doi: 10.1126/science.1202007. Epub 2011 Apr 28.

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

Affiliations
Free article

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

Jun-Young Seo et al. Science. .
Free article

Abstract

Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown. We show that HCMV-induced viperin disrupts cellular metabolism to enhance the infectious process. Viperin interaction with the viral protein vMIA resulted in viperin relocalization from the endoplasmic reticulum to the mitochondria. There, viperin interacted with the mitochondrial trifunctional protein that mediates β-oxidation of fatty acids to generate adenosine triphosphate (ATP). This interaction with viperin, but not with a mutant lacking the viperin iron-sulfur cluster-binding motif, reduced cellular ATP generation, which resulted in actin cytoskeleton disruption and enhancement of infection. This function of viperin, which was previously attributed to vMIA, suggests that HCMV has coopted viperin to facilitate the infectious process.

Comment in

Similar articles

See all similar articles

Cited by 79 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback