Poliovirus type 1 enters the human host through intestinal M cells

P Siciński; J Rowiński; J B Warchoł; Z Jarzabek; W Gut; B Szczygieł; K Bielecki; G Koch

doi:10.1016/0016-5085(90)91290-m

Poliovirus type 1 enters the human host through intestinal M cells

Gastroenterology. 1990 Jan;98(1):56-8. doi: 10.1016/0016-5085(90)91290-m.

Authors

P Siciński¹, J Rowiński, J B Warchoł, Z Jarzabek, W Gut, B Szczygieł, K Bielecki, G Koch

Affiliation

¹ Department of Histology and Embryology, Medical School, Warsaw, Poland.

PMID: 2152776
DOI: 10.1016/0016-5085(90)91290-m

Abstract

It was demonstrated by electron microscopy that after in vitro incubation of human Peyer's patches with poliovirus type 1, either Sabin or Mahoney strain, poliovirus particles adhere specifically to and are endocytosed by intestinal epithelial M cells. These findings suggest that M cells in humans are the site of poliovirus penetration of the intestinal epithelial barrier.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biological Transport
Endocytosis
Epithelial Cells
Female
Humans
In Vitro Techniques
Male
Microscopy, Electron
Middle Aged
Peyer's Patches / microbiology*
Poliovirus / physiology*
Virion / ultrastructure