How to use biomarkers efficiently in acute kidney injury

Kidney Int. 2011 May;79(10):1047-50. doi: 10.1038/ki.2011.21.


We discuss the performance of novel biomarkers in acute kidney injury (AKI). Comparison of the areas under the receiver operating characteristic curves of several biomarkers with some clinical and/or routine biochemical outcome parameters reveals that none of the biomarkers has demonstrated a clear additional value beyond the traditional approach in clinical decision making in patients with AKI. Unscrutinized use of these biomarkers may distract from adequate clinical evaluation and carries the risk of worse instead of better patient outcome.

Publication types

  • Comment

MeSH terms

  • Acute Kidney Injury / diagnosis*
  • Acute-Phase Proteins / urine
  • Area Under Curve
  • Biomarkers / urine*
  • Humans
  • Lipocalin-2
  • Lipocalins / urine
  • Proto-Oncogene Proteins / urine


  • Acute-Phase Proteins
  • Biomarkers
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Proto-Oncogene Proteins