Helicobacter pylori and its effects on human health and disease

Arch Iran Med. 2011 May;14(3):192-9.


H. pylori is now a known cause of gastric and duodenal ulcers, noncardia gastric cancer and gastric MALT lymphoma. In addition, the role of this microorganism in causing or preventing a large number of other diseases has been investigated, some of which include esophageal cancer, functional dyspepsia, gastroesophageal reflux disease, asthma, cardiovascular diseases, iron deficiency anemia and idiopathic thrombotic purpura. This article reviews the evidence for these associations and provides suggestions for further research.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / epidemiology*
  • Anemia, Iron-Deficiency / epidemiology
  • Asthma / epidemiology*
  • Carcinoma, Squamous Cell / epidemiology*
  • Cardiovascular Diseases / epidemiology
  • Dyspepsia / epidemiology
  • Esophageal Neoplasms / epidemiology*
  • Esophageal Squamous Cell Carcinoma
  • Gastroesophageal Reflux / epidemiology
  • Helicobacter Infections / epidemiology*
  • Helicobacter pylori*
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / epidemiology*
  • Peptic Ulcer / epidemiology
  • Protective Factors
  • Purpura, Thrombocytopenic, Idiopathic / epidemiology
  • Risk Factors
  • Stomach Neoplasms / epidemiology*

Supplementary concepts

  • Adenocarcinoma Of Esophagus