The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the anti-diabetic drug metformin, as a potential anti-cancer therapy

Med Hypotheses. 2011 Aug;77(2):171-3. doi: 10.1016/j.mehy.2011.04.001. Epub 2011 May 6.


In the animal models of glucose dependent cancer growth, the growth is decreased 15-30% through the use of low-carbohydrate, calorically restricted and/or ketogenic diet. The remaining growth depends on glucose formed by the liver-kidney gluconeogenesis as is the case in the cancer cachexia. It is hypothesized that a new treatment for cancer diseases should be explored which includes the ketogenic diet combined with the inhibition of gluconeogenesis by the anti-diabetic drug metformin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / drug effects*
  • Cachexia / metabolism*
  • Diet, Ketogenic / methods*
  • Gluconeogenesis / physiology
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Metformin / pharmacology
  • Neoplasms / diet therapy*
  • Neoplasms / drug therapy*


  • Blood Glucose
  • Hypoglycemic Agents
  • Metformin