Multifaceted roles for lipids in viral infection

Trends Microbiol. 2011 Jul;19(7):368-75. doi: 10.1016/j.tim.2011.03.007. Epub 2011 Apr 29.


Viruses have evolved complex and dynamic interactions with their host cell. In recent years we have gained insight into the expanding roles for host lipids in the virus life cycle. In particular, viruses target lipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their replication. This review highlights examples from different viruses that illustrate the importance of these diverse virus-lipid interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Membrane / metabolism
  • Endocytosis
  • Host-Pathogen Interactions
  • Lipid Metabolism*
  • Membrane Lipids / metabolism*
  • Receptors, Virus / metabolism*
  • Signal Transduction
  • Virus Diseases / metabolism
  • Virus Internalization
  • Virus Replication*
  • Viruses / metabolism*


  • Membrane Lipids
  • Receptors, Virus