Tau regulates the subcellular localization of calmodulin

Biochem Biophys Res Commun. 2011 May 13;408(3):500-4. doi: 10.1016/j.bbrc.2011.04.082. Epub 2011 Apr 21.

Abstract

Lack of tau expression in neuronal cells results in a change in the expression of few genes. However, little is known about how tau regulates gene expression. Here we show that the presence of tau could alter the subcellular localization of calmodulin, a protein that could be located at the cytoplasm or in the nucleus. Nuclear calmodulin binds to co-transcription factors, regulating the expression of genes like calbindin. In this work, we have found that in neurons containing tau, a higher proportion of calmodulin is present in the cytoplasm compared with neurons lacking tau and that an increase in cytoplasmic calmodulin correlates with a higher expression of calbindin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calbindins
  • Calmodulin / metabolism*
  • Cell Line, Tumor
  • Cells, Cultured
  • Gene Expression Regulation*
  • Hippocampus / cytology
  • Hippocampus / metabolism
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Neurons / metabolism*
  • S100 Calcium Binding Protein G / genetics*
  • tau Proteins / genetics
  • tau Proteins / metabolism*

Substances

  • Calbindins
  • Calmodulin
  • Mapt protein, mouse
  • S100 Calcium Binding Protein G
  • tau Proteins