Anti-Listeria activities of Galleria mellonella hemolymph proteins

Appl Environ Microbiol. 2011 Jun;77(12):4237-40. doi: 10.1128/AEM.02435-10. Epub 2011 Apr 29.

Abstract

We report the use of antimicrobial hemolymph proteins from the model host Galleria mellonella as an inhibitor for various Listeria strains, providing a novel source for antilisterial therapeutics. We also have shown that specific virulence-associated genes known to mediate antimicrobial resistance of Listeria in mammalian models indicated a similar function in Galleria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / genetics
  • Antimicrobial Cationic Peptides / pharmacology*
  • Gene Deletion
  • Hemolymph / chemistry*
  • Insect Proteins / genetics
  • Insect Proteins / pharmacology*
  • Lepidoptera
  • Listeria / drug effects*
  • Listeria / growth & development
  • Survival Analysis

Substances

  • Antimicrobial Cationic Peptides
  • Insect Proteins