Necrotizing soft-tissue infections

Crit Care Med. 2011 Sep;39(9):2156-62. doi: 10.1097/CCM.0b013e31821cb246.


Objective: To provide a contemporary review of the diagnosis and management of necrotizing soft-tissue infections.

Data sources: Scientific literature and internet sources.

Study selection: Major articles of importance in this area.

Conclusions: The mortality for necrotizing soft-tissue infections appears to be decreasing, possibly due to improved recognition and earlier delivery of more effective therapy. Establishing a diagnosis and initiating treatment as soon as possible provides the best opportunity for a good outcome.

Publication types

  • Review

MeSH terms

  • Acid-Base Imbalance / therapy
  • Anti-Infective Agents / therapeutic use
  • Debridement
  • Fasciitis, Necrotizing / diagnosis
  • Fasciitis, Necrotizing / pathology
  • Fasciitis, Necrotizing / therapy
  • Fluid Therapy
  • Humans
  • Necrosis
  • Soft Tissue Infections / diagnosis*
  • Soft Tissue Infections / microbiology
  • Soft Tissue Infections / pathology
  • Soft Tissue Infections / therapy


  • Anti-Infective Agents