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. 2011 Jun;14(6):688-90.
doi: 10.1038/nn.2826. Epub 2011 May 1.

Neuronal Activity Drives Matching of Pre- And Postsynaptic Function During Synapse Maturation

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Neuronal Activity Drives Matching of Pre- And Postsynaptic Function During Synapse Maturation

Louise Kay et al. Nat Neurosci. .

Abstract

The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses only gradually become functionally matched and that this process is dependent on ongoing electrical activity.

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