PAPP-A levels of late pregnancy in preeclampsia and HELLP syndrome

Arch Gynecol Obstet. 2012 Jan;285(1):45-9. doi: 10.1007/s00404-011-1912-z. Epub 2011 Apr 30.


Purpose: To determine the relationship between pregnancy-associated plasma protein-A (PAPP-A) levels and preeclampsia and HELLP syndrome at last trimester and to investigate if the severity of preeclampsia would be associated with PAPP-A levels.

Methods: Four groups were constructed; mild-preeclampsia group consisted of 19 women, severe-preeclampsia group 17, HELLP group 5 and control group 32 women. All groups were matched strictly for gestational age at last trimester. Maternal blood samples for PAPP-A were collected as soon as the patients were diagnosed as preeclampsia or HELLP syndrome at last trimester and compared.

Results: Mean ages of participants, parity, gestational week, and fetal weights were similar. Mean PAPP-A levels were significantly higher in preeclampsia and HELLP groups compared to control group. PAPP-A levels were not different among mild-severe preeclampsia and HELLP groups. There was significant, positive and strong correlation between gestational age and PAPP-A level and also between fetal weight and PAPP-A levels (correlation coefficents = 0.83 and 0.78 respectively).

Conclusion: PAPP-A level at last trimester increases in all mild-severe preeclampsia and HELLP syndrome, but is not predictive for severity of preeclampsia or HELLP syndrome.

MeSH terms

  • Adult
  • Female
  • Gestational Age
  • HELLP Syndrome / blood
  • HELLP Syndrome / diagnosis*
  • Humans
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnosis*
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, Third
  • Pregnancy-Associated Plasma Protein-A / analysis*
  • Prospective Studies
  • Severity of Illness Index
  • Young Adult


  • Pregnancy-Associated Plasma Protein-A