Migraine and depression: common pathogenetic and therapeutic ground?

Neurol Sci. 2011 May;32 Suppl 1:S85-8. doi: 10.1007/s10072-011-0545-0.


Migraine and depression are recognized as comorbid disorders on the basis of several epidemiological data and on the possibility of shared mechanisms. On the other hand, there is a lack of studies concerning therapeutic strategies in patients with this comorbidity. The aim of this paper is to briefly review the literature about the migraine and depression comorbidity and on the putative common neurobiological mechanisms, as well to discuss the possible therapeutic options in treating patients with both disorders.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • Comorbidity
  • Depression / drug therapy
  • Depression / epidemiology*
  • Depression / physiopathology*
  • Humans
  • Migraine Disorders / drug therapy
  • Migraine Disorders / epidemiology*
  • Migraine Disorders / physiopathology*