Cytogenetic and molecular observations in human and experimental salivary gland tumors

Cancer Genet Cytogenet. 1990 Feb;44(2):153-67. doi: 10.1016/0165-4608(90)90042-9.


The chromosomal banding patterns in 189 benign and malignant salivary gland tumors are reviewed. For comparison, karyotypic data from a recent series of polyoma virus-induced salivary gland tumors in the mouse are discussed. Special interest is focused on the relationships between the highly specific patterns of translocations and deletions in these tumors and different genes involved in neoplasia, in particular oncogenes, and tumor suppressor genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenoma, Pleomorphic / genetics
  • Animals
  • Carcinoma / genetics
  • Carcinoma, Adenoid Cystic / genetics
  • Chromosome Aberrations*
  • Chromosome Banding
  • Humans
  • Karyotyping
  • Mice
  • Polyomavirus
  • Salivary Gland Neoplasms / etiology
  • Salivary Gland Neoplasms / genetics*
  • Tumor Virus Infections / genetics