Stimulation of Muscle Protein Synthesis by Whey and Caseinate Ingestion After Resistance Exercise in Elderly Individuals

Scand J Med Sci Sports. 2011 Dec;21(6):e372-83. doi: 10.1111/j.1600-0838.2011.01318.x. Epub 2011 Apr 28.

Abstract

Sarcopenia is a well-known phenomenon in elderly individuals and resistance exercise together with sufficient amino acid (AA) availability has proved to be a counteractive implement. However, the source of AA and supplement timing require further investigation. The objective was to compare muscle protein synthesis (MPS) to intakes of whey and caseinate after heavy resistance exercise in healthy elderly individuals, and, furthermore, to compare the timing effect of caseinate intake. Twenty-four elderly men and women (mean ± SEM; 68 ± 1 years) were randomized to one of four groups: caseinate intake before exercise (CasPre), caseinate intake immediately after exercise (CasPost), whey intake immediately after exercise (Whey), or intake of a non-caloric control drink (Control). Muscle myofibrillar and collagen fractional synthesis rates (FSR) were measured by a primed continuous infusion of L-[1-(13) C]leucine using labeled proteins during a 6-h recovery period. No differences were observed in muscle myofibrillar and collagen FSR with Whey (0.09 ± 0.01%/h) compared with CasPost (0.09 ± 0.003%/h), and it did not differ between CasPre (0.10 ± 0.01%/h) and CasPost. MPS does not differ with whey and caseinate feeding immediately after heavy resistance exercise in elderly individuals, and MPS is similar with caseinate ingestion before and after exercise.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Caseins / administration & dosage
  • Caseins / metabolism*
  • Collagen / metabolism
  • Dietary Proteins / administration & dosage
  • Dietary Proteins / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Milk Proteins / administration & dosage
  • Milk Proteins / metabolism*
  • Muscle Development / physiology
  • Muscle Proteins / biosynthesis*
  • Resistance Training*
  • Whey Proteins

Substances

  • Caseins
  • Dietary Proteins
  • Milk Proteins
  • Muscle Proteins
  • Whey Proteins
  • Collagen