Engineering plant resistance by constructing chimeric receptors that recognize damage-associated molecular patterns (DAMPs)

FEBS Lett. 2011 Jun 6;585(11):1521-8. doi: 10.1016/j.febslet.2011.04.043. Epub 2011 Apr 27.


An efficient sensing of danger and a rapid activation of the immune system are crucial for the survival of plants. Conserved pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and endogenous molecular patterns, which are present only when the tissue is infected or damaged (damage-associated molecular patterns or DAMPs), can act as danger signals and activate the plant immune response. These molecules are recognized by surface receptors that are indicated as pattern recognition receptors (PRRs). In this paper we summarize recent information on oligogalacturonides (OGs), a class of DAMPs that is released from the extracellular matrix of the plant cell during pathogen attack or wounding. We also describe the characteristics of the Arabidopsis Wall-Associated Kinase 1 (WAK1), a PRR recently identified as a receptor of OGs and discuss the use of WAK1, PRRs and chimeric receptors to engineer resistance in crop plants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Arabidopsis Proteins / metabolism
  • Genetic Engineering / methods*
  • Humans
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Pectins / metabolism
  • Plants / genetics*
  • Plants / immunology*
  • Plants / metabolism
  • Protein Kinases / metabolism
  • Receptors, Pattern Recognition / chemistry
  • Receptors, Pattern Recognition / genetics*
  • Receptors, Pattern Recognition / metabolism*
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / genetics*
  • Recombinant Fusion Proteins / metabolism*


  • Arabidopsis Proteins
  • Membrane Proteins
  • Receptors, Pattern Recognition
  • Recombinant Fusion Proteins
  • Pectins
  • Protein Kinases
  • WAK1 protein, Arabidopsis