Inhibitory activity of cinnamon bark species and their combination effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase

Plant Foods Hum Nutr. 2011 Jun;66(2):143-8. doi: 10.1007/s11130-011-0226-4.


Inhibition of α-glucosidase and pancreatic α-amylase is one of the therapeutic approaches for delaying carbohydrate digestion, resulting in reduced postprandial glucose. The aim of this study was to evaluate the phytochemical analysis and the inhibitory effect of various cinnamon bark species against intestinal α-glucosidase and pancreatic α-amylase. The results showed that the content of total phenolic, flavonoid, and condensed tannin ranged from 0.17 to 0.21 g gallic acid equivalent/g extract, from 48.85 to 65.52 mg quercetin equivalent/g extract, and from 0.12 to 0.15 g catechin equivalent/g extract, respectively. The HPLC fingerprints of each cinnamon species were established. Among cinnamon species, Thai cinnamon extract was the most potent inhibitor against the intestinal maltase with the IC(50) values of 0.58 ± 0.01 mg/ml. The findings also showed that Ceylon cinnamon was the most effective intestinal sucrase and pancreatic α-amylase inhibitor with the IC(50) values of 0.42 ± 0.02 and 1.23 ± 0.02 mg/ml, respectively. In addition, cinnamon extracts produced additive inhibition against intestinal α-glucosidase and pancreatic α-amylase when combined with acarbose. These results suggest that cinnamon bark extracts may be potentially useful for the control of postprandial glucose in diabetic patients through inhibition of intestinal α-glucosidase and pancreatic α-amylase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acarbose / pharmacology*
  • Animals
  • Catechin / analysis
  • Chromatography, High Pressure Liquid
  • Cinnamomum zeylanicum / chemistry*
  • Drug Combinations
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Flavonoids / analysis
  • Gallic Acid / analysis
  • Glycoside Hydrolase Inhibitors*
  • Inhibitory Concentration 50
  • Pancreatic alpha-Amylases / antagonists & inhibitors*
  • Plant Bark / chemistry
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Quercetin / analysis
  • Rats
  • Sri Lanka
  • Sucrase / antagonists & inhibitors
  • Swine
  • Tannins / analysis


  • Drug Combinations
  • Enzyme Inhibitors
  • Flavonoids
  • Glycoside Hydrolase Inhibitors
  • Plant Extracts
  • Tannins
  • Gallic Acid
  • Catechin
  • Quercetin
  • Pancreatic alpha-Amylases
  • Sucrase
  • Acarbose