Genome-wide approaches to the study of adaptive gene expression evolution: systematic studies of evolutionary adaptations involving gene expression will allow many fundamental questions in evolutionary biology to be addressed

Bioessays. 2011 Jun;33(6):469-77. doi: 10.1002/bies.201000094. Epub 2011 Apr 28.


The role of gene expression in evolutionary adaptation has been a subject of debate for over 40 years. cis-regulation of transcription has been proposed to be the primary source of morphological novelty in evolution, though this is based on only a handful of examples. Recently the first genome-wide studies of gene expression adaptation have been published, giving us an initial global view of this process. Systematic studies such as these will allow a number of key questions currently facing the field of gene expression evolution to be addressed.

Publication types

  • Review

MeSH terms

  • Adaptation, Biological*
  • Animals
  • Biological Evolution*
  • Epistasis, Genetic
  • Gene Expression Regulation*
  • Gene Regulatory Networks
  • Genome-Wide Association Study*
  • Humans
  • Models, Genetic
  • Mutation
  • Selection, Genetic