Circulating osteogenic cells: implications for injury, repair, and regeneration

J Bone Miner Res. 2011 Aug;26(8):1685-93. doi: 10.1002/jbmr.370. Epub 2011 May 2.


The aim of this review is to provide a critical reading of recent literature pertaining to the presence of circulating, fluid-phase osteoblastic cells and their possible contribution to bone formation. We have termed this group of cells collectively as circulating osteogenic precursor (COP) cells. We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Humans
  • Osteoblasts / pathology*
  • Osteogenesis*
  • Regeneration*
  • Stem Cells / cytology
  • Wound Healing*