MOB control: reviewing a conserved family of kinase regulators

Cell Signal. 2011 Sep;23(9):1433-40. doi: 10.1016/j.cellsig.2011.04.007. Epub 2011 Apr 21.

Abstract

The family of Mps One binder (MOB) co-activator proteins is highly conserved from yeast to man. At least two different MOB proteins have been identified in every eukaryote analysed to date. Initially, yeast genetics revealed essential roles for Mob1p and Mob2p in the regulation of mitotic exit and cell morphogenesis. Studies in flies then showed that dMOB1/MATS is a core component of Hippo signalling. Loss of dMOB1 resulted in increased cell proliferation and decreased cell death, suggesting that MOB1 acts as tumour suppressor protein. Recent work focused primarily on mammalian cells has shown how hMOB1 can regulate NDR/LATS kinases, a function that can to be counteracted by hMOB2. Here we summarise and discuss our current knowledge of this emerging protein family, with emphasis on subcellular localisation, protein-protein interactions and biological functions in apoptosis, mitosis, morphogenesis, cell proliferation and centrosome duplication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Apoptosis
  • Cell Cycle Proteins / metabolism
  • Cell Proliferation
  • Centrosome / metabolism
  • Drosophila / growth & development
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mitosis*
  • Morphogenesis
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Phylogeny
  • Protein Binding
  • Protein-Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Cell Cycle Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • MOB1 protein, S cerevisiae
  • MOB1A protein, human
  • MOB1B protein, human
  • MOB2 protein, S cerevisiae
  • Mob2 protein, Drosophila
  • Phosphoproteins
  • Saccharomyces cerevisiae Proteins
  • Tumor Suppressor Proteins
  • Protein-Serine-Threonine Kinases
  • STK38 protein, human