New agents for prevention of ultraviolet-induced nonmelanoma skin cancer

Semin Cutan Med Surg. 2011 Mar;30(1):6-13. doi: 10.1016/j.sder.2011.01.003.

Abstract

With the incidence of nonmelanoma skin cancer on the rise, current prevention methods, such as the use of sunscreens, have yet to prove adequate to reverse this trend. There has been considerable interest in identifying compounds that will inhibit or reverse the biochemical changes required for skin cancers to develop, either by pharmacologic intervention or by dietary manipulation. By targeting different pathways identified as important in the pathogenesis of nonmelanoma skin cancers, a combination approach with multiple agents or the addition of chemopreventative agents to topical sunscreens may offer the potential for novel and synergistic therapies in treating nonmelanoma skin cancer.

MeSH terms

  • Anilides / therapeutic use
  • Carcinoma, Basal Cell / drug therapy*
  • Carcinoma, Basal Cell / etiology
  • Carcinoma, Basal Cell / prevention & control*
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / prevention & control*
  • Carotenoids / therapeutic use
  • Cell Transformation, Neoplastic / radiation effects
  • Cyclooxygenase 2 Inhibitors / therapeutic use
  • DNA Repair Enzymes / therapeutic use
  • Diet, Fat-Restricted*
  • Eflornithine / therapeutic use
  • Flavonoids / therapeutic use
  • Genistein / therapeutic use
  • Humans
  • Keratosis, Actinic / drug therapy*
  • Keratosis, Actinic / etiology
  • Keratosis, Actinic / prevention & control*
  • Lycopene
  • Phenols / therapeutic use
  • Photochemotherapy*
  • Polyphenols
  • Pyridines / therapeutic use
  • Retinoids / therapeutic use
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / etiology
  • Skin Neoplasms / prevention & control*
  • Sunscreening Agents / therapeutic use
  • Ultraviolet Rays / adverse effects

Substances

  • Anilides
  • Cyclooxygenase 2 Inhibitors
  • Flavonoids
  • HhAntag691
  • Phenols
  • Polyphenols
  • Pyridines
  • Retinoids
  • Sunscreening Agents
  • Carotenoids
  • Genistein
  • DNA Repair Enzymes
  • Lycopene
  • Eflornithine