The transcriptional and signalling networks of pluripotency

Nat Cell Biol. 2011 May;13(5):490-6. doi: 10.1038/ncb0511-490.


Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can exist in vitro. Here we review the recent advances in studying the transcriptional regulatory networks that define pluripotency, and elaborate on how manipulation of signalling pathways can modulate pluripotent states to varying degrees.

Publication types

  • Review

MeSH terms

  • Animals
  • Histones / metabolism
  • Humans
  • Mice
  • MicroRNAs / metabolism
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism*
  • RNA, Untranslated / metabolism
  • Signal Transduction*
  • Transcription Factors / metabolism
  • Transcription, Genetic*


  • Histones
  • MicroRNAs
  • RNA, Untranslated
  • Transcription Factors