Emerging models and paradigms for stem cell ageing

Nat Cell Biol. 2011 May;13(5):506-12. doi: 10.1038/ncb0511-506.


Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cellular Senescence*
  • DNA Damage
  • Epigenesis, Genetic
  • Genomic Instability
  • Humans
  • Models, Biological*
  • Stem Cells / cytology*
  • Transcription, Genetic