iPS cells forgive but do not forget

Nat Cell Biol. 2011 May;13(5):523-5. doi: 10.1038/ncb0511-523.


Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

Publication types

  • Comment
  • News

MeSH terms

  • Humans
  • Pluripotent Stem Cells / cytology*
  • Transcription, Genetic