The role of Notch signaling in adult neurogenesis

Mol Neurobiol. 2011 Aug;44(1):7-12. doi: 10.1007/s12035-011-8186-0. Epub 2011 May 4.


Neurogenesis occurs throughout adulthood in the mammalian brain. Newly born neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, and there is growing evidence that adult neurogenesis is important for various brain functions. Continuous neurogenesis is achieved by the coordinated proliferation and differentiation of adult neural stem cells. In this review, we discuss the recent findings concerning the roles of Notch signaling in adult neural stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / metabolism
  • Animals
  • Humans
  • Neural Stem Cells / metabolism
  • Neurogenesis* / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction* / genetics


  • Receptors, Notch