AA amyloidosis associated with hepatitis B

Nephrol Dial Transplant. 2011 Jul;26(7):2407-12. doi: 10.1093/ndt/gfr224. Epub 2011 May 4.


We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).

Publication types

  • Case Reports

MeSH terms

  • Amino Acid Sequence
  • Amyloidosis / complications*
  • Amyloidosis / metabolism
  • Child
  • Chromatography, Liquid
  • Hepatitis B / complications*
  • Hepatitis B / metabolism
  • Hepatitis B virus / pathogenicity*
  • Humans
  • Kidney Glomerulus / physiopathology*
  • Lasers
  • Male
  • Microdissection
  • Molecular Sequence Data
  • Nephrotic Syndrome / etiology*
  • Nephrotic Syndrome / metabolism
  • Prognosis
  • Serum Amyloid A Protein / metabolism
  • Tandem Mass Spectrometry


  • Serum Amyloid A Protein