The effect of TMS on visual motion sensitivity: an increase in neural noise or a decrease in signal strength?

J Neurophysiol. 2011 Jul;106(1):138-43. doi: 10.1152/jn.00746.2010. Epub 2011 May 4.

Abstract

The underlying mechanisms of action of transcranial magnetic stimulation (TMS) are still a matter of debate. TMS may impair a subject's performance by increasing neural noise, suppressing the neural signal, or both. Here, we delivered a single pulse of TMS (spTMS) to V5/MT during a motion direction discrimination task while concurrently manipulating the level of noise in the motion stimulus. Our results indicate that spTMS essentially acts by suppressing the strength of the relevant visual signal. We suggest that TMS may induce a pattern of neural activity that complements the ongoing activation elicited by the sensory signal in a manner that partially impoverishes that signal.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Discrimination, Psychological / physiology
  • Discrimination, Psychological / radiation effects
  • Female
  • Humans
  • Male
  • Motion Perception / physiology
  • Motion Perception / radiation effects*
  • Psychomotor Performance / physiology
  • Psychomotor Performance / radiation effects
  • Signal Transduction / radiation effects
  • Transcranial Magnetic Stimulation*
  • Visual Cortex / physiology
  • Visual Cortex / radiation effects*
  • Young Adult