Kidney complications in EMC virus-induced diabetes in conventional DBA/2 male mice

Jikken Dobutsu. 1990 Jan;39(1):113-6. doi: 10.1538/expanim1978.39.1_113.


Conventional DBA/2 male mice of about 9 weeks of age were inoculated by intraperitoneally injecting EMC virus M variant (10(4) TCID50/0.1 ml/animal) which is passaged in mice. The mice which tested positive for glycosuria and hyperglycemia were examined histopathologically 2 or 5 months after inoculation. The kidneys were examined for thickening of Bowman's capsule and the mesangial matrix. These changes were more clearly observable 5 months after inoculation than they were 2 months after inoculation.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / pathology*
  • Diabetic Nephropathies / pathology*
  • Encephalomyocarditis virus
  • Kidney / pathology*
  • Male
  • Mice
  • Mice, Inbred DBA