Linalool from rosewood (Aniba rosaeodora Ducke) oil inhibits adenylate cyclase in the retina, contributing to understanding its biological activity

Phytother Res. 2012 Jan;26(1):73-7. doi: 10.1002/ptr.3518. Epub 2011 May 5.


Rosewood oil (RO) (Aniba rosaeodora Ducke) is rich in linalool, a monoterpene alcohol, which has well studied anxiolytic, sedative and anticonvulsant effects. The inhibition of the increases in cAMP protects against seizures in a diversity of models of epilepsy. In this paper, the principal aim was to investigate the effects of RO, (±)-linalool and (-)-linalool) on adenylate cyclase. They were tested in chick retinas and forskolin was used to stimulate the enzyme target. The phosphodiesterase inhibitor, 4-(3-butoxy-4-methoxybenzyl)-imidazolidin-2-one, and the non-selective adenosine receptor antagonist 3-isobutyl-methyl-xanthine (IBMX), were used to control the participation of phosphodiesterase and adenosine receptors in the resulting effects, respectively. The cAMP accumulation was measured by enzyme immune assay (EIA). Rosewood oil, (-)-linalool and (±)-linalool inhibited exclusively the cAMP accumulation stimulated by forskolin, even when adenosine receptors were blocked with IBMX. The IC(50) values (in μ m concentration range) calculated from their concentration response-curves were not statistically different, however, the compounds presented a different relative efficacy. These results extend the range of subcellular mechanisms underlying the relaxant action of linalool on the central nervous system.

MeSH terms

  • 1-Methyl-3-isobutylxanthine / pharmacology
  • Acyclic Monoterpenes
  • Adenylyl Cyclase Inhibitors*
  • Animals
  • Central Nervous System Agents / pharmacology*
  • Chickens
  • Colforsin / pharmacology
  • Cyclic AMP / metabolism
  • Enzyme Inhibitors / pharmacology
  • Inhibitory Concentration 50
  • Lauraceae / chemistry*
  • Monoterpenes / pharmacology*
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Phosphoric Diester Hydrolases / metabolism
  • Plant Extracts / pharmacology*
  • Receptors, Purinergic P1 / metabolism
  • Retina / drug effects*
  • Retina / enzymology


  • Acyclic Monoterpenes
  • Adenylyl Cyclase Inhibitors
  • Central Nervous System Agents
  • Enzyme Inhibitors
  • Monoterpenes
  • Oils, Volatile
  • Plant Extracts
  • Receptors, Purinergic P1
  • Colforsin
  • linalool
  • Cyclic AMP
  • Phosphoric Diester Hydrolases
  • 1-Methyl-3-isobutylxanthine