Long-term effects of aerobic plus resistance training on the metabolic syndrome and adiponectinemia in obese adolescents

J Clin Hypertens (Greenwich). 2011 May;13(5):343-50. doi: 10.1111/j.1751-7176.2010.00388.x. Epub 2010 Nov 8.


The metabolic syndrome is an emerging clinical problem and different kinds of interventions have emphasized that healthy eating and exercise are crucial to its control. The aim of this study was to identify whether aerobic training plus resistance training (AT+RT) is more effective than AT on improving features of the metabolic syndrome and adiponectinemia in obese adolescents. A total of 30 adolescents (aged 15-19 years, body mass index ≥95 percentile) were enrolled in the program. All patients were diagnosed with the metabolic syndrome and submitted to 1 year of interdisciplinary intervention. They were divided into two groups: AT (n=15) and AT+RT (n=15). Blood samples were collected to analyze glycemia and lipid profiles. Adiponectin was measured by enzyme-linked immunosorbent assay, and insulin resistance was measured by homeostasis model assessment of insulin resistance index. After short- and long-term intervention, both groups presented a significant reduction in body mass, body mass index, fat mass, and visceral fat. Indeed, the AT+RT group had significantly higher changes throughout the intervention in body composition, total cholesterol, waist circumference, glucose, and adiponectin. Although important clinical parameters were ameliorated with AT, the AT+RT group showed more effective improvements in metabolic profiles and adiponectinemia. These findings suggest a clinical role of AT+RT in the control of metabolic syndrome in pediatric populations.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adolescent
  • Blood Glucose / metabolism
  • Body Composition / physiology
  • Body Mass Index
  • Cholesterol / blood
  • Eating
  • Exercise*
  • Female
  • Humans
  • Life Style
  • Longitudinal Studies
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / physiopathology
  • Metabolic Syndrome / therapy*
  • Obesity / blood*
  • Obesity / therapy*
  • Resistance Training*
  • Waist Circumference


  • Adiponectin
  • Blood Glucose
  • Cholesterol