Abstract
This work studied a relationship between HO-1/CO system and lipid peroxidation with consequent effects on liver functions and NOS-2. We focused on curcumin pretreatment in rat toxic model of d-galactosamine and lipopolysaccharide. Hepatocyte viability, lipid peroxidation, antioxidant status, ALT and AST were evaluated. HO-1 and NOS-2 expressions and respective enzyme activity were determined. Curcumin caused decreases in ALT and AST levels as well as in lipid peroxidation. Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model.
Copyright © 2011 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Antioxidants / pharmacology
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Antioxidants / therapeutic use*
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Aspartate Aminotransferases / blood
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Carbon Monoxide / metabolism*
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Chemical and Drug Induced Liver Injury / drug therapy*
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Chemical and Drug Induced Liver Injury / metabolism
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Curcuma / chemistry
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Curcumin / pharmacology
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Curcumin / therapeutic use*
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Disease Models, Animal
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Galactosamine
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Heme Oxygenase-1 / metabolism*
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Lipid Peroxidation / drug effects
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Lipopolysaccharides
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Liver / cytology
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Liver / drug effects*
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Liver / metabolism
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Male
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Nitric Oxide Synthase Type II / metabolism
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Phytotherapy*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Rats
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Rats, Wistar
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Signal Transduction
Substances
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Antioxidants
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Lipopolysaccharides
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Plant Extracts
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Galactosamine
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Carbon Monoxide
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Nitric Oxide Synthase Type II
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Heme Oxygenase-1
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Aspartate Aminotransferases
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Alanine Transaminase
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Curcumin