Monoterpenoids from the aerial parts of Aruncus dioicus var. kamtschaticus and their antioxidant and cytotoxic activities
- PMID: 21546250
- DOI: 10.1016/j.bmcl.2011.04.043
Monoterpenoids from the aerial parts of Aruncus dioicus var. kamtschaticus and their antioxidant and cytotoxic activities
Abstract
The aerial parts of Aruncus dioicus var. kamtschaticus afforded five new monoterpenoids (1-5): 4-(erythro-6,7-dihydroxy-9-methylpent-8-enyl)furan-2(5H)-one (1, aruncin A), 2-(8-ethoxy-8-methylpropylidene)-5-hydroxy-3,6-dihydro-2H-pyran-4-carboxylic acid (2, aruncin B), 4-(hydroxymethyl)-6-(8-methylprop-7-enyl)-5,6-dihydro-2H-pyran-2-one-11-O-β-D-glucopyranoside (3, aruncide A), (3S,4S,5R,10R)-3-(10-ethoxy-11-hydroxyethyl)-4-(5-hydroxy-7-methylbut-6-enyl)oxetan-2-one-11-O-β-D-glucopyranoside (4, aruncide B), and (3S,4S,5R,7R)-5-(9-methylprop-8-enyl)-1,6-dioxabicyclo[3,2,0]heptan-2-one-7-(hydroxymethyl)-12-O-β-D-glucopyranoside (5, aruncide C). Compound 2 showed potent cytotoxicity against Jurkat T cells with an IC(50) value of 17.15 μg/mL. In addition, compounds 7 and 10 exhibited moderate antioxidant activity with IC(50) values of 46.3 and 11.7 μM, respectively.
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
Similar articles
-
Monoterpenoids from the traditional North Italian vegetable Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae).Food Chem. 2017 Apr 15;221:1851-1859. doi: 10.1016/j.foodchem.2016.10.090. Epub 2016 Oct 22. Food Chem. 2017. PMID: 27979172
-
Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus.Bioorg Med Chem Lett. 2012 Jan 15;22(2):945-53. doi: 10.1016/j.bmcl.2011.12.023. Epub 2011 Dec 9. Bioorg Med Chem Lett. 2012. PMID: 22197393
-
Pregnane steroidal glycosides and their cytostatic activities.Glycobiology. 2011 May;21(5):619-24. doi: 10.1093/glycob/cwq203. Epub 2010 Dec 8. Glycobiology. 2011. PMID: 21147757
-
A new cytotoxic iridoid from Callicarpa nudiflora.Nat Prod Res. 2010 Jun;24(10):899-904. doi: 10.1080/14786410802267544. Nat Prod Res. 2010. PMID: 19753502
-
Studies on the chemical constituents and biological activities of ixeris.Chem Biodivers. 2013 Aug;10(8):1373-91. doi: 10.1002/cbdv.201100234. Chem Biodivers. 2013. PMID: 23939790 Review. No abstract available.
Cited by
-
Quality Characteristics of Substitute Meat Patties Developed Using Aruncus dioicus var. kamtschaticus Hara.Foods. 2022 May 5;11(9):1341. doi: 10.3390/foods11091341. Foods. 2022. PMID: 35564064 Free PMC article.
-
Enhancing Efficiency of Natural Product Structure Revision: Leveraging CASE and DFT over Total Synthesis.Molecules. 2023 Apr 28;28(9):3796. doi: 10.3390/molecules28093796. Molecules. 2023. PMID: 37175206 Free PMC article.
-
Glycolipids Derived from the Korean Endemic Plant Aruncus aethusifolius Inducing Glucose Uptake in Mouse Skeletal Muscle C2C12 Cells.Plants (Basel). 2024 Feb 23;13(5):608. doi: 10.3390/plants13050608. Plants (Basel). 2024. PMID: 38475455 Free PMC article.
-
Aruncin B: Synthetic Studies, Structural Reassignment and Biological Evaluation.Chemistry. 2017 Nov 21;23(65):16525-16534. doi: 10.1002/chem.201702949. Epub 2017 Oct 30. Chemistry. 2017. PMID: 28815753 Free PMC article.
-
Potent anti-aging activity of Aruncus dioicus, a native plant of Ulleung-do, South Korea, in CCD-986sk fibroblasts via suppression of matrix metalloproteinases.J Nat Med. 2012 Oct;66(4):631-6. doi: 10.1007/s11418-012-0633-3. Epub 2012 Feb 17. J Nat Med. 2012. PMID: 22350144
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
