The major objective in endodontic therapy is to achieve complete chemomechanical debridement of the entire root canal system. This can be accomplished with biomechanical instrumentation and chemical irrigation. Various endodontic irrigants, such as sodium hypochlorite, chlorhexidene, and iodine potassium iodide, are available, each having its own advantages with some limitations. MTAD, a new endodontic irrigant, has been introduced to fulfill these limitations. MTAD is a mixture of doxycycline, citric acid, and a detergent (Tween 80). Since its introduction, it is a material that has been researched extensively for its properties. This article presents a review on the numerous properties of MTAD, such as antimicrobial activity, smear layer- and pulp-dissolving capability, effect on dentin and adhesion, and biocompatibility.
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