The burden of disease of retinal vein occlusion: review of the literature

Eye (Lond). 2011 Aug;25(8):981-8. doi: 10.1038/eye.2011.92. Epub 2011 May 6.


Retinal vein occlusion (RVO) is the second most common cause of vision loss due to retinal vascular disease. A literature review was undertaken to understand the epidemiology, clinical consequence, current practice patterns, and cost of RVO. Pertinent articles were identified by computerized searches of the English language literature in MEDLINE supplemented with electronic and manual searches of society/association proceedings and bibliographies of electronically identified sources. Population-based studies report a prevalence rate of 0.5-2.0% for branch RVO and 0.1-0.2% for central RVO. The 15-year incidence rate is estimated to be 1.8% for branch RVO and 0.2% for central RVO. Patients with RVO report lower vision-related quality of life than those without ocular disease. Available treatment options are limited. Until recently there was no treatment for central RVO. Laser photocoagulation is only recommended for branch RVO in patients who have not experienced severe vision loss. Emerging evidence on the effectiveness of intravitreal anti-vascular endothelial growth factor therapy and dexamethasone intravitreal implant is promising. Information on the treatment patterns and cost of RVO is extremely limited with one retrospective analysis of secondary insurance payment data identified and limited to the United States population only. A better understanding of the economic and societal impact of RVO will help decision makers evaluate emerging medical interventions for this sight-threatening disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cost of Illness
  • Humans
  • Incidence
  • Light Coagulation / economics
  • Middle Aged
  • Prevalence
  • Retinal Vein Occlusion* / economics
  • Retinal Vein Occlusion* / epidemiology
  • Retinal Vein Occlusion* / therapy
  • Tomography, Optical Coherence / economics
  • Vision Disorders / economics
  • Vision Disorders / etiology
  • Vision Disorders / therapy