Cloning of the T gene required in mesoderm formation in the mouse

Nature. 1990 Feb 15;343(6259):617-22. doi: 10.1038/343617a0.


The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allantois, and die at about 10 days of gestation. We have isolated the T gene using a combination of molecular and genetic techniques, thus making molecular tools available to study processes underlying mesoderm formation in the mouse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Deletion
  • Chromosome Mapping
  • Cloning, Molecular*
  • DNA Transposable Elements
  • Embryo, Mammalian / physiology
  • Genes*
  • Mesoderm / physiology*
  • Mice
  • Molecular Sequence Data
  • Restriction Mapping


  • DNA Transposable Elements