The effect of late preterm birth on mortality of infants with major congenital heart defects

J Perinatol. 2012 Jan;32(1):51-4. doi: 10.1038/jp.2011.50. Epub 2011 May 5.


Objective: We evaluated the effect of late preterm delivery (34 to 36 weeks) on hospital mortality of infants with congenital heart defects (CHDs).

Study design: Retrospective record review of infants with major CHD born at or after to 34 weeks, cared for in a single tertiary perinatal center between 2002 and 2009. Factors associated with death before discharge from the hospital were ascertained using univariate and multivariate analyses.

Result: Of the 753 infants with CHD, 117 were born at late preterm. Using logistic regression analysis, white race (OR; 95% CI) (0.60; 0.39 to 0.95), late preterm delivery (2.70; 1.69 to 4.33), and need for intubation in the delivery room (3.15; 1.92 to 5.17) were independently associated with hospital death.

Conclusion: Late preterm birth of infants with major CHDs was independently associated with increased risk of hospital death compared with delivery at more mature gestational ages.

MeSH terms

  • Analysis of Variance
  • Female
  • Gestational Age
  • Heart Defects, Congenital / mortality*
  • Hospital Mortality
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature, Diseases / mortality*
  • Multivariate Analysis
  • Pregnancy
  • Premature Birth / mortality
  • Retrospective Studies
  • Risk Factors