Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment

World J Gastroenterol. 2011 Apr 28;17(16):2063-9. doi: 10.3748/wjg.v17.i16.2063.


Esophageal adenocarcinoma is a major cause of cancer death in men in the developed world. Continuing poor outcomes with conventional therapies that predominantly target apoptosis pathways have lead to increasing interest in treatments that target the cell cycle. A large international effort has led to the development of a large number of inhibitors, which target cell cycle kinases, including cyclin-dependent kinases, Aurora kinases and polo-like kinase. Initial phase I/II trials in solid tumors have often demonstrated only modest clinical benefits of monotherapy. This may relate in part to a failure to identify the patient populations that will gain the most clinical benefit. Newer compounds lacking the side effect profile of first-generation compounds may show utility as adjunctive treatments targeted to an individual's predicted response to treatment.

Keywords: Aurora kinases; Cell cycle; Cyclin-dependent kinase; Esophageal adenocarcinoma; Polo-like kinase.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / enzymology
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use*
  • Cell Cycle / drug effects*
  • Cell Cycle / physiology
  • Clinical Trials as Topic
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / therapeutic use*
  • Esophageal Neoplasms / drug therapy*
  • Esophageal Neoplasms / enzymology
  • Humans
  • Male


  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Cyclin-Dependent Kinases