Aim: To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China.
Methods: In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sex-matched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.
Results: The frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic frequencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism.
Conclusion: The T allele of Ku80 G-1401T may be associated with the development of gastric cancer.
Keywords: Carcinogenesis; Gastric cancer; Ku80; Polymorphism; Promoter.