Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer

World J Gastroenterol. 2011 Apr 28;17(16):2131-6. doi: 10.3748/wjg.v17.i16.2131.


Aim: To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China.

Methods: In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sex-matched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.

Results: The frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic frequencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism.

Conclusion: The T allele of Ku80 G-1401T may be associated with the development of gastric cancer.

Keywords: Carcinogenesis; Gastric cancer; Ku80; Polymorphism; Promoter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antigens, Nuclear / genetics*
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Ku Autoantigen
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic / genetics*
  • Risk Factors
  • Stomach Neoplasms / genetics*


  • Antigens, Nuclear
  • DNA-Binding Proteins
  • Xrcc6 protein, human
  • Ku Autoantigen