[Effects of Astragalus polysaccharide on nephritis induced by cationic bovine serum albumin in rats]

Zhong Yao Cai. 2010 Dec;33(12):1913-6.
[Article in Chinese]

Abstract

Objective: To study the effects of Astragalus polysaccharide on nephritis induced by cationic bovine serum albumin in rats.

Methods: C-BSA induced nephritis model was utilized in rats. The effects of Astragalus polysaccharide on this model were investigated.

Results: Proteinuria of the Astragalus polysaccharide group was alleviated. The pathological damages of the Astragalus polysaccharide group were less severe in comparison with the model group. The Astragalus polysaccharide group could improve erythrocyte immune function and increase the CD35 and CD44s contents of red blood cells.

Conclusion: Astragalus polysaccharide exerts a good effect in alleviating glomerular immune inflammation and improving erythrocyte immune function in the treatment of C-BSA induced nephritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • Astragalus propinquus / chemistry*
  • Cattle
  • Creatinine / blood
  • Disease Models, Animal
  • Erythrocytes / immunology*
  • Erythrocytes / metabolism
  • Glomerulonephritis / drug therapy*
  • Glomerulonephritis / immunology*
  • Glomerulonephritis / metabolism
  • Glomerulonephritis / pathology
  • Kidney / immunology
  • Kidney / metabolism
  • Kidney / pathology
  • Male
  • Polysaccharides / pharmacology*
  • Polysaccharides / therapeutic use
  • Proteinuria / urine
  • Rats
  • Rats, Wistar
  • Serum Albumin, Bovine

Substances

  • Antigens, CD
  • Polysaccharides
  • Serum Albumin, Bovine
  • Creatinine