A web of interactions at the ends

Neal F Lue; Min Hsu

doi:10.1016/j.molcel.2011.04.014

A web of interactions at the ends

Mol Cell. 2011 May 6;42(3):269-71. doi: 10.1016/j.molcel.2011.04.014.

Authors

Neal F Lue¹, Min Hsu

Affiliation

¹ Department of Microbiology and Immunology, W.R. Hearst Microbiology Research Center, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. nflue@med.cornell.edu

Abstract

The synthesis of telomeric DNA by telomerase entails repeated cycles of reverse transcription on a short RNA template. In this issue of Molecular Cell, Robart and Collins (2011) describe a set of interactions between human telomerase RNA, protein domains, and the substrate DNA that drives the intricate reaction cycle.

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